Dr Deborah Mason

MBChB, FRACP

Neurologist, MS Research

New Zealand Brain Research Institute, Christchurch

Consultant neurologist

Department of Neurology, Canterbury District Health Board, Christchurch

Clinical Senior Lecturer

Department of Medicine, University of Otago, Christchurch

I am a Consultant neurologist at Christchurch hospital and currently lead the MS research group whose principal focus is clinical research into the disease multiple sclerosis. In 2006 the MS research group completed a nationwide study into the prevalence of MS identifying 3,000 people with MS in New Zealand. This study lead to an international collaboration (ANZgene) involving over 1500 New Zealand MS patients who contributed genetic samples resulting in the identification of 29 novel genes in MS. The group’s current research projects include a nationwide incidence study of MS and a Vitamin D intervention trial in people with early MS. Other research interests include finding imaging biomarkers for MS pathology and prognosis. We are currently performing an MRI study measuring perfusion, diffusion and resting-state functional MRI on grey and white matter in patients with early and established relapsing onset multiple sclerosis.

Publications

Provided on request for non-commercial personal use by researchers.

2016

Download Disability profile of multiple sclerosis in New Zealand.
Alla, S., Pearson, J. F., Taylor, B. V., Miller, D. H., Clarke, G., Richardson, A., Willoughby, E., Abernethy, D. A., Sabel, C. E., Mason, D. F. (2016). Disability profile of multiple sclerosis in New Zealand. Journal of Clinical Neuroscience, 28, 97-101. 10.1016/j.jocn.2015.09.020

2015

Download An investigation of the relationship between latitude and multiple sclerosis severity in New Zealand.
Alla, S., Pearson, J. F., Taylor, B. V., Roxburgh, R., Clarke, G., Miller, D. H., Richardson, A., Abernethy, D. A., Willoughby, E., Sabel, C. E., Mason, D. F. (2015). An investigation of the relationship between latitude and multiple sclerosis severity in New Zealand. Multiple Sclerosis. 10.1177/135245851560590
Download A new era in the treatment of multiple sclerosis.
Broadley, S. A., Barnett, M. H., Boggild, M., Brew, B. J., Butzkueven, H., Heard, R., Hodgkinson, S., Kermode, A. G., Lechner-Scott, J., Macdonell, R. A., Marriott, M., Mason, D. F., Parratt, J., Reddel, S. W., Shaw, C. P., Slee, M., Spies, J. M., Taylor, B. V., Carroll, W. M., Kilpatrick, T. J., . . . Willoughby, E. (2015). A new era in the treatment of multiple sclerosis. Medical Journal of Australia, 203(3), 139-141. 10.5694/mja14.01218
Download Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis.
Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging. 10.1016/j.pscychresns.2015.10.00
Download A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.
Gu, B. J., Field, J., Dutertre, S., Ou, A., Kilpatrick, T. J., Lechner-Scott, J., Scott, R., Lea, R., Taylor, B. V., Stankovich, J., Butzkueven, H., Gresle, M., Laws, S. M., Petrou, S., Hoffjan, S., Akkad, D. A., Graham, C. A., Hawkins, S., Glaser, A., Bedri, S. K., . . . Wiley, J. S. (2015). A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis. Human Molecular Genetics, 24(19), 5644-54. 10.1093/hmg/ddv278

2014

Download Multiple sclerosis in New Zealand.
Alla, S. , Mason, D.F. (2014). Multiple sclerosis in New Zealand. Journal of Clinical Neuroscience, Online preprint. 10.1016/j.jocn.2013.09.009
Download The increasing prevalence of multiple sclerosis in New Zealand.
Alla, S., Pearson, J., Debernard, L., Miller, D. , Mason, D. (2014). The increasing prevalence of multiple sclerosis in New Zealand. Neuroepidemiology, 42, 154-160. 10.1007/s00702-013-1123-9
Download Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis.
Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A., Dalrymple-Alford, J. C., Miller, D. H. , Mason, D.F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 85. 10.1136/jnnp-2013-305612
Download Multiple sclerosis in New Zealand Maori.
Pearson, J. F., Alla, S., Clarke, G., Taylor, B. V., Miller, D. H., Richardson, A., Mason, D.F. (2014). Multiple sclerosis in New Zealand Maori. Multiple Sclerosis, 20(14), 1892-1895. 10.1177/1352458514535130
Download Optic neuritis.
Toosy, A. T., Mason, D. F., Miller, D.H. (2014). Optic neuritis. Lancet Neurology, 13, 83-99. 10.1016/S1474-4422(13)70259-X

2013

Download (2013), Analysis of Immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
The International Multiple Sclerois Genetics Consortium (2013). (2013), Analysis of Immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.  Nature Genetics, 45, 1353-1360.

2012

Download A review of interferon use in patients with relapsing remitting multiple sclerosis in the Canterbury region, New Zealand 2000-2006.
Byrne, S., Mason, D. (2012). A review of interferon use in patients with relapsing remitting multiple sclerosis in the Canterbury region, New Zealand 2000-2006.  New Zealand Medical Journal,  125 (1350), 37-44.
Richardson, A. K., Clarke, G., Sabel, C. E., Pearson, J. F., Mason, D. F., Taylor, B.V. (2012). Method for identifying eligible individuals for a prevalence survey in the absence of a disease register or population register.  International Medical Journal,  42, 1207-1212.
Download Geographical variations in sex ratio trends over time in multiple sclerosis.
Trojano, M., Lucchese, G., Graziano, G., Taylor, B. V., Simpson, S. J., Lepore, V., Grand'maison, F., Duquette, P., Izquierdo, G., Grammond, P., Amato, M. P., Bergamaschi, R., Giuliani, G., Boz, C., Hupperts, R. et al. , on behalf of the MSBase Study Group and the New Zealand MS Prevalence Study Group (2012). Geographical variations in sex ratio trends over time in multiple sclerosis.  PLoS One,  7, e48078.. 10.1371/journal.pone.0048078

2011

Download and the Wellcome Trust Case Control Consortium 2 (WTCCC2) (2011), Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
The International Multiple Sclerosis Genetics Consortium (2011). and the Wellcome Trust Case Control Consortium 2 (WTCCC2) (2011), Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.  Nature,  476, 214-219. 10.1038/nature10251

2010

Download A review of tuberculous meningitis at Auckland City Hospital, New Zealand.
Anderson, N. E., Somaratne, J., Mason, D. F., Holland, D., Thomas, M.G. (2010). A review of tuberculous meningitis at Auckland City Hospital, New Zealand.  Journal of Clinical Neuroscience,  17, 1018-1022. 10.1016/j.jocn.2010.01.007
Download Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand.
Anderson, N. E., Somaratne, J., Mason, D. F., Holland, D., Thomas, M.G. (2010). Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand.  Journal of Clinical Neuroscience,  17, 1114-1118. 10.1016/j.jocn.2010.01.006
Download MS prevalence in New Zealand, an ethnically and latitudinally diverse country.
Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., Sabel, C. (2010). MS prevalence in New Zealand, an ethnically and latitudinally diverse country. Multiple Sclerosis,  16, 1422-1431. 10.1177/1352458510379614

2009

Download Acute inflammatory encephalomyelitis following Campylobacter enteritis associated with high titre antiganglioside GM1 IgG antibodies.
Young, J. W., Mason, D. F., Taylor, B.V. (2009). Acute inflammatory encephalomyelitis following Campylobacter enteritis associated with high titre antiganglioside GM1 IgG antibodies.  Journal of Clinical Neuroscience,  16, 597-8. 10.1016/j.jocn.2008.06.024

2005

Download Detection of focal cerebral hemisphere lesions using the neurological examination.
Anderson, N. E., Mason, D. F., Fink, J. N., Bergin, P. S., Charleston, A. J. , Gamble, G.D. (2005). Detection of focal cerebral hemisphere lesions using the neurological examination. Journal of Neurology Neurosurgery and Psychiatry with Practical Neurology, 76, 545-549. 10.1136/jnnp.2004.043679

2004

Canadian MS Working Group (2004). Treatment optimization in multiple sclerosis. Canadian Journal of Neurological Science, 31, 157-168.

Abstracts and Short papers

2014

Alla, S, Pearson, J, Richardson, A, Mason, D. (2014). The incidence of multiple sclerosis in New Zealand 2013: a population- based study (Abstract). Multiple Sclerosis Journal, 20:(S1), 220.

2013

Alla, S., Pearson, J. , Mason, D. (2013). The increasing prevalence of multiple sclerosis in New Zealand (Abstract).  Multiple Sclerosis, 19(S11), 345.
Alla, S., Roxburgh, R., Pearson, J., Taylor, B. , Mason, D. (2013). Latitude is not associated with multiple sclerosis disability in New Zealand (Abstract).  Multiple Sclerosis,  9(S11), 46.
Debernard, L., Alla, S., Melzer, T., Van Stockum, S., Graham, C., Dalrymple-Alford, J., Miller, DH, Mason, D (2013). Cortical perfusion is associated with cognitive function in relapsing remitting multiple sclerosis patients (Abstract).  Multiple Sclerosis,  19(S11), 171.

2012

Alla, S., Pearson, J., Clarke, G., Taylor, B. , Mason, D. (2012). The low prevalence of multiple sclerosis in Maori is not responsible for the latitude gradient in New Zealand (Abstract).  Multiple Sclerosis, 18(S4), 88.
Alla, S., Pearson, J., Clarke, G., Taylor, B. , Mason, D. (2012). The clinical characteristics of multiple sclerosis in Maori are homogeneous with that of the national cohort (Abstract). Multiple Sclerosis, 18(S4), 324.